A01AB22 - Doxycycline |
Probably not porphyrinogenic |
PNP |
Rationale
Potent inhibitor of CYP3A4; MI-complex formation? Conflicting references. Several Swedish observations of non-porphyrinogenicity. Probably insignificant hepatic load in local dental use.
Chemical description
Tetracycline is a broad-spectrum antibiotic with alkylamino group used in local treatment of tooth-pocket infections. Mainly unmetabolized but CYPs appear to be involved to some extent since CYP-inducing drugs result in an increase in its metabolism. Inhibitor of CYP3A4 (MI-complex?). The concentration of the antibiotic in blood does not exceed 1 ug/ml.
Personal communication
Thunell: A few observations of tolerance. Andersson: Several observations of tolerance.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Chlamydial infection: which antibiotic for patients with acute intermittent porphyria?
Smith JR, Forster SM. Genitourin Med. 1989 Jun; 65(3):199-200.
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2759614 |
| Other sources | ||
| 2. | French List
Centre Français des Porphyries
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| 3. | Porphyrin metabolism and the Porphyrias [Book Chapter]
Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.
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Tradenames
Ligosan 
Ligosan 
Adjusan 
Atridox · Doxycyclin · Ligosan 
Ligosan 
Fucidox 
Doxycycline 
Doksiciklin