N05BA06 - Lorazepam |
Probably not porphyrinogenic |
PNP |
Rationale
Directly conjugated with glucuronic acid. Several references consider it safe.
Chemical description
Benzodiazepine anxiolytic. Eliminated by direct conjugation with glucuronic acid. Conflicting experimental evidence of porphyrinogenicity (Martindale) MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use with care. EPI-list: safe South African list: use French list: use Australian list: safe (conflicting evidence) See Holoryd S et al. Psychotropic drugs in acute... (PMID10511069): safe (n=1). Kauppinen and Mustajoki. Prognosis of acute porphyria... Medicine 1992; 71: 1-13: tolerated (N=1). Used in porphyria ward (Sweden)
IPNet drug reports
Uneventful use reported in 12 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Psychotropic drugs in acute intermittent porphyria.
Holroyd S, Seward RL. Clin Pharmacol Ther. 1999 Sep; 66(3):323-5.
|
10511069 |
| 2. | Prognosis of acute porphyria: occurrence of acute attacks, precipitating factors, and associated diseases.
Kauppinen R, Mustajoki P. Medicine (Baltimore). 1992 Jan; 71(1):1-13.
|
1549056 |
Tradenames
Lambutrix · Lorazepam · Temelor · Xilmac · Zambaxo 
Lambutrix · Lorazepam · Serenase · Temesta 
Lorazepam · Temesta 
Donix · Lorazepam · Orfidal · Placinoral · Temelor 
Loranxil · Lorazepam 
Control · Lorans · Lorazepam · Lorxagen · Tavor 
Anxiar · Temelor 
Lorazepam · Rativor · Sedazin · Temesta 
Ativan · Lorazepam 
Lirezid · Lorazepam · Rativor · Temelor · Temesta 
Ativan · Lorazepam · Tavor · Temesta 
Lorazepam · Rativor · Tavor · Temesta 
Lorabex · Lorafen · Lorazepam 
Ativan · Lorazepam 
Ativan · Lorapam · Lorazepam · Lorzem 
Lorans · Lorazepam 
Ativan · Lorazepam 
Lambutrix · Lorazepam · Temesta 
Lorazepam · Rativor · Temesta 
Dalixen · Lirezid · Lorafen · Lorans · Lorazepam 
Lorafen · Lorazepam · Temelor 
Lorans · Temelor 
Lorazepam · Lorsilan · Losepan 
Lorsilan · Temelor 
Ativan · Dorm · Lorafen · Loram · Lorazepam · Lorsilan · Tavor · Temesta 
Temelor 
Lorazapam